Summary of results

• The three strains ensure a rapid and sustainable recolonization of the vaginal flora.
• They maintain a Low vaginal pH and one dominance of protective lactobacilli .
• Reduction of recurrences of vaginosis and candidiasis of 45 to 60% .
• Extension of the infection-free periods observed.
• Lactobacillus reuteri product of the reuterin , a natural antimicrobial active against Candida And Gardnerella .
• Women report a marked improvement in intimate comfort :
  - Less losses,
  - Less irritation
  - Fewer post-antibiotic imbalances.
• The effects are synergistic And well tolerated clinically .

Clinical efficacy of the “Intimate Well-being” formula and its probiotics

Synergistic benefits and documented mechanisms

✔ Rapid and lasting restoration of protective vaginal flora

The 3 strains are dominant lactobacilli naturally present in a healthy vaginal microbiota (low pH, low bacterial diversity dominated by lactic acid-producing lactobacilli).

- L. crispatus : key strain of the healthy vaginal microbiota, capable of dominating the vaginal niche and persisting there for a long time (studies with CTV-05, IP174178).
- L. rhamnosus: strong ability to adhere to the vaginal epithelium and strengthen local defenses.
- L. reuteri : producer of lactic acid and reuterin, a powerful natural antimicrobial against Candida, Gardnerella and other vaginal pathogens.

✔ Reduction in recurrences of recurrent vaginal infections (BV and mycoses)

- 45 to 60% reduction in the risk of recurrence of bacterial vaginosis (BV), according to randomized clinical studies (notably with L. crispatus and the combination L. rhamnosus + L. reuteri ).
- Significant reduction in recurrent vulvovaginal candidiasis in women prone to repeated mycoses (studies with L. rhamnosus LCR35 and L. reuteri RC-14).
- Extension of the time between two episodes of intimate infections.
- Prevention of imbalances caused by antibiotic therapy, stress, hormonal fluctuations.

✔ Powerful local antimicrobial and anti-inflammatory actions

- Production of lactic acid (rapid and lasting drop in vaginal pH below 4): inhibits Candida, Gardnerella vaginalis, Trichomonas, and opportunistic pathogens.
- Production of reuterin (L. reuteri ): natural antimicrobial active against Candida albicans and bacteria responsible for BV.
- Inhibition of the adhesion of pathogens to vaginal cells (physical and biological barrier effect).

✔ Rebalancing the vaginal microbiota after disruption (antibiotics, mycoses, periods, sexuality)

- Rapid and lasting colonization of protective lactobacilli after disturbances.
- Reduction of abnormal losses, unpleasant odors, irritations, dryness and discomfort.
- Overall improvement of intimate comfort and quality of life for women.

✔ Effects demonstrated by oral and vaginal routes

Oral route: indirect action by ascending recolonization (intestine-vagina axis), systemic modulation of mucosal immunity.

Vaginal route: direct, local and rapid action.

Clinical studies confirm the efficacy of both routes of administration , with a preference for oral administration. in prolonged prevention and the vaginal in attack treatment.