Validated by Science

Each BodyCheckup supplement incorporates active ingredients whose effectiveness is supported by published clinical studies.

CLINICAL STUDIES

Microbiota Boost

Clinical studies

Description

Clinical studies related to Microbiote Boost aim to:

  • validate the effectiveness of the 8 individually well-documented probiotic strains.
  • assess their impact on digestive health, particularly in irritable bowel syndrome (IBS), diarrhea, constipation and post-antibiotic disorders.
  • analyze their ability to restore the balance of disturbed intestinal microbiota.
  • examine their role in reducing intestinal permeability and chronic inflammation.
  • explore the immunomodulatory effects specific to each strain to justify a synergistic action in the formula.

References :

  • B. bifidum MIMBb75 (RCT SII) – PubMed
  • B. infantis 35624 (IBS + immunity) – Gastrojournal
  • B. longum BB536 (senior immunity) – PubMed
  • L. plantarum 299V (RCT IBS) – PubMed
  • L. plantarum CCFM8610 (anti-inflammatory IBS) – RSC
  • L. acidophilus (immunity review) – MDPI
  • L. casei Shirota (DAA) – BMJ / Cambridge
  • L. rhamnosus GG (pediatric diarrhea) – Meta-analysis – PubMed
  • L. rhamnosus GG (children's respiratory infections) – PubMed
  • L. lactis PH3-05 (preclinical study) – MDPI
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Results

  • Rebalancing of the intestinal microbiota : reduction of opportunistic pathogens, increase of beneficial bacteria, better diversity (95% improvement observed vs. 15% under placebo.)
  • Strengthening the intestinal barrier : reduced permeability, better protection against inflammation.
  • Significant reduction in symptoms of irritable bowel syndrome (IBS) : abdominal pain, bloating, diarrhea, digestive emergencies.
  • Support of local and systemic immunity : Improvement of the vaccine response (e.g., influenza)
  • Reduction of intestinal and systemic inflammation : decrease in pro-inflammatory cytokines, increase in anti-inflammatory cytokines (IL-10).
  • Improvement of intestinal transit : normalization of stools, reduction in the frequency and duration of diarrhea (particularly post-antibiotic and infectious).
  • Lower incidence of upper respiratory infections in children (colds, ear infections), with reduced duration of symptoms and better viral resistance.
  • Indirect effect on general comfort and quality of life : better digestion, less discomfort, improved quality of life scores in several trials.
  • Improved digestion and absorption : digestive enzyme stimulation and better bioavailability of nutrients (observed in particular with L. lactis ).
  • Restoration of the microbiota after antibiotic therapy : prevention of antibiotic-associated diarrhea and Clostridioides difficile infections.
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Bio slimming B420

Clinical study

Description

  • The studies investigated the effects of Bifidobacterium lactis B420 in overweight or obese adults.
  • Main objectives:
    - Assess the impact on body composition (reduction in fat mass).
    - Measure the effects on intestinal health (permeability, inflammation).
    - Study the influence on appetite and metabolic markers .
  • Studies conducted under clinical and preclinical conditions, with or without associated prebiotic fibers .
  • Purpose: To validate the potential of B420 as a natural solution for weight management and the prevention of metabolic disorders.
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Results

  • B420 resulted in a significant reduction in total fat mass (–4.5%) and waist circumference (–2.4 cm).
  • A spontaneous decrease in caloric intake of approximately 300 kcal/day was observed.
  • The combination with prebiotic fibers reinforced the effects on:
    - Satiety ,
    - Intestinal permeability (reduction of zonulin),
    - Inflammation (decrease in ultrasensitive CRP).
  • Preclinical studies have shown:
    - Improved insulin sensitivity ,
    - A reduction in circulating endotoxins .
  • Bottom Line: B420 is one of the most well-documented probiotic strains for reducing fat mass and supporting gut and metabolic health.
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Intimate well-being

Clinical study

Description

  • The studies investigated the efficacy of Lactobacillus crispatus, L. rhamnosus and L. reuteri .
  • Main objectives:
    -Restore a protective vaginal microbiota .
    -Prevent recurrent infections : bacterial vaginosis and candidiasis.
    -Reduce imbalances linked to antibiotic therapy, stress or hormonal variations.
  • Clinical trials also evaluated:
    - The impact on vaginal pH .
    - Reduction of intimate symptoms : discharge, irritation, dryness.
  • Improving the quality of life of women .
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Results

  • The three strains ensure rapid and lasting recolonization of the vaginal flora.
  • They maintain a low vaginal pH and a dominance of protective lactobacilli .
  • Reduction of recurrences of vaginosis and candidiasis by 45 to 60% .
  • Extension of infection-free periods observed.
  • Lactobacillus reuteri produces reuterin , a natural antimicrobial active against Candida and Gardnerella .
  • Women report a marked improvement in intimate comfort :
    - Less losses,
    - Less irritation
    - Fewer post-antibiotic imbalances.
  • The effects are synergistic and clinically well tolerated .
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Organic Ashwagandha

Clinical study

Description

  • Clinical studies have evaluated the adaptogenic effects of ashwagandha , traditionally used in Ayurvedic medicine.
  • Main objectives:
    - Reduce stress and anxiety .
    - Improve sleep and cognition .
    - Optimize physical performance and hormonal balance .
    - Support fertility , immunity and metabolic health .
  • The trials included stressed adults , insomniacs , athletes , and subjects with hormonal or cognitive disorders .
  • The studies aimed to:
    -Confirm the effectiveness of ashwagandha.
    -Determine the optimal doses according to the indications.
    -Document its tolerance and safety of use .
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Results

  • Stress reduction : reduction of cortisol by –14 to –20%
  • Decreased anxiety : large effect (SMD ≈ –1.5).
  • Improved sleep : quality, duration and ease of falling asleep.
  • Strengthening cognitive abilities : memory and concentration.
  • Increased strength and endurance in athletes.
  • Hormonal effects :
    - Increased testosterone and improved sperm quality .
    - Improvement of female sexual function .
  • Immune support : increase in lymphocytes , antibodies and NK cells .
  • Metabolic balance : regulation of blood sugar, blood lipids and possible improvement of mild hypothyroidism .
  • Anti-inflammatory and antioxidant action contributing to overall well-being.
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Microbiota boost for children

Clinical study

Description

  • The studies evaluate the efficacy of the combination of L. acidophilus, L. rhamnosus and B. infantis in children aged 1 to 15 years.
  • Three axes are explored: immunity/infections , functional digestive disorders (IBS, pain), and acute diarrhea (including post-antibiotics).
  • The objective is to validate the pediatric use of these strains in well-tolerated multi-strain formulas.
  • Research also focuses on safety , duration of treatment and optimal dosage .
  • This work supports the targeted use of probiotics in prevention and treatment in children .
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Results

  • The combination of L. acidophilus, L. rhamnosus and B. infantis shows significant efficacy in children in several areas.
  • It reduces respiratory infections (less fever, cough and need for antibiotics).
  • It relieves pain and bloating associated with irritable bowel syndrome, with good tolerance.
  • In case of acute diarrhea , it accelerates the return to normal transit .
  • It prevents post-antibiotic diarrhea , with excellent clinical tolerance .
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Hair, nails and skin complex

Clinical study

Description

  • Studies evaluate the effectiveness of specific nutrients on the growth, strength and quality of hair and nails .
  • They cover plants (nettle, horsetail), minerals (zinc, magnesium), B vitamins (B5, B6, B8), amino acids (cystine, MSM) and collagen peptides .
  • The research combines in vitro studies, controlled clinical trials and observational studies .
  • The goal is to identify bioactive compounds that strengthen keratin and stimulate hair follicles .
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Results

  • Silica, L-cystine, MSM, marine collagen, zinc and biotin improve the quality of hair and nails, especially in cases of deficiency.
  • Nettle and horsetail show positive effects in cell culture or in combination use, but lack strong isolated clinical evidence
  • Hydrolyzed collagen stimulates nail growth and follicular activity .
  • Combined formulas containing several of these active ingredients are the most effective .
  • They help strengthen hair , thicken nails and reduce hair loss or breakage .
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Detox emergency

Clinical study

Description

  • Urgence Détox studies evaluate the effectiveness of medicinal plants in protecting and regenerating the liver and analyze their impact on oxidative stress and improving digestive functions.
  • Research focuses on extracts such as artichoke, milk thistle or turmeric , and their effect on liver markers (ALT, AST) , bile production and digestive enzyme activity .
  • The data combine clinical trials (e.g., hepatic steatosis) and preclinical studies on antioxidant and anti-inflammatory mechanisms.
  • Certain plants are also studied for their positive effects on the intestinal microbiota , in a synergistic approach to natural detoxification .
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Results

  • Clinical studies show that artichoke, milk thistle and turmeric significantly improve liver markers (ALT, AST) and symptoms of liver diseases.
  • Dandelion and rosemary show promising antioxidant and hepatoprotective effects , particularly in preclinical studies .
  • Peppermint relieves functional digestive disorders , such as bloating.
  • Lemon balm and fumitory support digestion and help modulate the intestinal microbiota .
  • All of these plants act in synergy on liver detox , reduction of oxidative stress and digestive comfort .
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Emergency intestinal crisis

Clinical study

Description

  • The studies aim to evaluate the effectiveness of a specific combination of probiotics on acute and chronic digestive disorders .
  • They examine their impact on infectious diarrhea , post-antibiotic imbalances , irritable bowel syndrome (IBS) , constipation and bloating .
  • The objective is also to measure their effects on the regulation of transit , the reduction of inflammation and the protection of the mucous barrier.
  • The approach is based on the synergy of three major strains acting in a complementary manner.
  • Research also evaluates high-dose tolerance and the benefits in prevention and treatment.
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Results

  • Rapid effectiveness from 4 weeks against acute and chronic digestive disorders clinically proven.
  • Reduction of infectious and post-antibiotic diarrhea , improvement of constipation , bloating and pain related to IBS .
  • All three strains strengthen the intestinal barrier , regulate the microbiota and support local immunity .
  • The probiotic synergy acts both curatively and preventively , with very good clinical tolerance .
  • The results are validated by several reference clinical trials on each of the strains.
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Omega 3

Clinical study

Description

  • Studies evaluate the preventive and therapeutic effects of omega-3 on various vital functions.
  • They demonstrate a reduction in cardiovascular risks , particularly after a heart attack (e.g. GISSI study).
  • Research confirms their role in maintaining age-related cognitive functions (e.g., MIDAS study).
  • Omega-3s are being studied for their effectiveness on eye health , particularly against AMD (e.g. AREDS2).
  • Several studies highlight their anti-inflammatory action , particularly in diseases such as arthritis.
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Results

  • Omega-3 EPA and DHA have demonstrated proven clinical efficacy in several health areas.
  • They reduce post-infarction cardiovascular mortality by 20% (GISSI study).
  • They improve memory in older people (MIDAS study)
  • They slow the progression of AMD (AREDS2 study) and reduce joint inflammation (Calder study).
  • These effects are obtained with doses of 850 to 900 mg/day , validated by reference clinical trials
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Magnesium bisglycinate

Clinical study

Description

  • Clinical studies on magnesium evaluate its effects on cardiovascular, nervous, muscular, immune and bone health.
  • They examine its role in regulating blood pressure , muscle recovery , stress management and improving sleep .
  • Magnesium is also being studied for its impact on carbohydrate metabolism , particularly in type 2 diabetes .
  • Other research focuses on its anti-inflammatory effects and its role in bone mineralization , especially in people who are deficient.
  • The overall objective is to identify the optimal forms, doses and durations of treatment for each indication.
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Results

  • Magnesium moderately lowers blood pressure in untreated hypertensive patients.
  • It improves glycemic control in diabetics, especially in cases of deficiency.
  • It does not reduce idiopathic cramps , but promotes muscle recovery and reduces stress , especially with vitamin B6.
  • It improves sleep and mood in vulnerable people
  • It supports bone health , modulates inflammation and has good clinical tolerance .
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Lactiplantibacillus plantarum

Clinical study

Description

  • Clinical studies are evaluating Lactiplantibacillus plantarum DR7 to prevent ENT infections , particularly in stressed adults.
  • They analyze its impact on mucosal immunity , by modulating the innate and adaptive immune response.
  • The objective is to measure the reduction in the frequency, duration and severity of infections.
  • The main study is a double-blind, randomized trial of 111 adults .
  • This research also explores the effect of DR7 as immune support in the context of chronic psychological stress .
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Results

  • Lactiplantibacillus plantarum DR7 significantly reduces the number, duration and severity of ENT infections.
  • It increases salivary IgA levels , strengthening local mucosal immunity.
  • It is well tolerated and remains effective in stressful situations.
  • Magnesium and Fibersol complement the immune effect by supporting the nervous system and intestinal balance .
  • The entire formula works in synergy to strengthen natural defenses .
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Organic Konjac

Clinical study

Description

  • Clinical studies are evaluating glucomannan (konjac fiber) for its effects on satiety and weight loss .
  • They examine its action on lipid and carbohydrate metabolism , particularly in diabetic people.
  • Glucomannan is being studied for its prebiotic effects promoting a healthy gut microbiota.
  • Its role on intestinal function , particularly in constipated subjects, is also documented.
  • The objective is to validate its usefulness in nutritional supplementation for obese, diabetic or constipated profiles.
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Results

  • Glucomannan increases satiety and significantly reduces appetite .
  • It lowers LDL and total cholesterol , and slightly improves fasting blood sugar .
  • It is effective against constipation , by increasing the frequency and quality of stools.
  • It favorably modifies the microbiota , in particular by enriching bifidobacteria
  • It promotes the production of short-chain fatty acids (SCFAs) , which are beneficial for intestinal health.
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Ultra pure glutamine

Clinical study

Description

  • Studies are evaluating glutamine for its role in muscle recovery and athletic support .
  • It is being studied to restore the integrity of the intestinal mucosa and reduce permeability .
  • Its effect is analyzed on immunity in the context of stress (resuscitation, cancer, intense exercise).
  • Glutamine may modulate oxidative stress and accelerate tissue healing
  • The goal is to define the optimal clinical conditions and dosages to obtain a measurable benefit.
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Results

  • Glutamine does not improve athletic performance , but it does promote muscle recovery .
  • It reduces certain stress markers (CK, CRP, MDA) after exercise
  • It is very effective in post-infectious IBS with intestinal hyperpermeability .
  • In oncology , it reduces the severity of mucositis induced by chemotherapy.
  • It has a slight anti-inflammatory and antioxidant effect , according to clinical studies.
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Vitamin and mineral supplements

Clinical study

Description

These studies confirm through clinical trials or meta-analyses the physiological effects of the ingredients: immunity, energy, cognition, stress, beauty, etc.

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Results

  • Immunity support with vitamin C, E, zinc, selenium and iodine – to better resist infections and regulate natural defenses.
  • Energy and vitality with B vitamins (B1, B2, B3, B5, B6, B9, B12) and magnesium – to reduce fatigue, support metabolism and improve concentration.
  • Nervous balance and mood : magnesium, B6, B12 and folates act synergistically on the management of stress, sleep and neurotransmitters (dopamine, serotonin).
  • Beauty of skin, hair and nails : biotin, zinc, vitamin A and B2 strengthen cell regeneration, skin elasticity and hair health.
  • Overall antioxidant protection : vitamins C, E, selenium and zinc neutralize free radicals and slow down cellular aging.
  • Muscle and bone function : Calcium, phosphorus, magnesium, and potassium support muscle contraction, bone density, and fluid balance.
  • Cognitive functions and memory : B1, B6, B12, folates and magnesium contribute to mental alertness, concentration and the prevention of cognitive fog.
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9 Amino Acid Supplements

Clinical study

Description

  • Studies evaluate the effects of essential amino acids (EAAs) on protein synthesis , physical performance , and muscle recovery .
  • They examine their role in reducing post-exercise fatigue and preventing muscle damage (DOMS, creatine kinase).
  • The research includes short- and long-term trials in young and old people .
  • The effectiveness of EAAs is studied when taken pre- or post-workout .
  • The objective is to validate their usefulness in maintaining muscle mass and optimizing sports performance.
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Results

  • EAAs stimulate muscle protein synthesis from 6 g and improve post-exercise nitrogen balance .
  • Taken before exercise , they reduce the loss of strength and lactatemia , limiting immediate fatigue.
  • Taken after exercise , they reduce muscle damage , pain and perceived fatigue .
  • Long-term studies show better maintenance of muscle mass , particularly in seniors.
  • EAAs provide overall recovery support , without noticeable side effects.
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Expert marine collagen

Clinical study

Description

  • Studies have evaluated the effectiveness of marine collagen hydrolysate, including Aquacol™.
  • Target population: adults showing signs of aging or tissue fragility.
  • Main objectives:
  • Improve the quality of skin, hair and nails
  • Measure the impact on wrinkles, hydration, skin elasticity.
  • Assess hair density, thickness and shedding.
  • Studies tested different doses to identify the optimal effect.
  • The safety and tolerability of the product were analyzed in healthy subjects.
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Results

  • Study carried out in 2023 on the effectiveness of Aquacol™ (1 to 5 g/d).
  • Significant aesthetic results observed:
  • 61.9% reduction in wrinkles.
  • Increased skin hydration by 22.9%.
  • 25.7% increase in capillary thickness.
  • 53.7% reduction in hair loss.
  • Improvement also noted in skin elasticity and hair density.
  • Perfect tolerance: 100% of subjects reported no adverse effects.
  • Conclusion: Aquacol™ provides comprehensive anti-aging support for skin, hair and nails.
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Berberine

Clinical study

Description

  • Clinical and preclinical studies have evaluated the effects of berberine on several metabolic parameters.
  • Main objectives:
    - Reduction in weight , blood sugar and blood lipids .
    - Improved intestinal health .
  • Targeted indications:
    -Type 2 diabetes ,
    -Metabolic syndrome ,
    -Hepatic steatosis ,
  • Digestive disorders , including IBS-D (irritable bowel syndrome with diarrhea predominance) .
  • Mechanisms of action explored:
  • Activation of AMPK (cellular energy regulation),
  • Modulation of the intestinal microbiota ,
  • Strengthening the intestinal barrier .
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Results

  • Reduction in fasting blood glucose of approximately –14 mg/dL.
  • Decrease in HbA1c from –0.5 to –2%, with improved insulin sensitivity (decrease in HOMA-IR).
  • Metabolic effects comparable to those of metformin .
  • Decreased triglycerides (~–24 mg/dL) and LDL cholesterol .
  • Moderate weight loss (~–2 kg).
  • Activation of fat burning (brown adipose tissue) and reduction of storage (browning of white tissue).
  • Rebalancing of the intestinal microbiota , repair of the mucosa and reduction of inflammation.
  • Improvement of digestive disorders , including IBS-D (irritable bowel with diarrhea).
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Strong hyaluronic acid

Clinical study

Description

  • Studies have evaluated the effectiveness of anti-aging oral active ingredients
  • Hyaluronic acid , Vitamins A, C, E , Selenium .
  • Main objectives:
    - Improve hydration , elasticity ,
    - Reduce wrinkles , Revive the complexion's radiance , Provide photoprotection .
  • The trials tested the active ingredients individually or in a combined formula .
  • The effects were measured using objective tools : profilometry, skin imaging, elasticity tests.
  • Final objective: to clinically validate the benefits on the health and beauty of the skin.
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Results

  • Oral hyaluronic acid (100–200 mg/day)
    - Improves skin hydration and elasticity .
    - Reduction of wrinkles in 8 to 12 weeks.
  • Vitamin C :
    - Stimulates collagen synthesis .
    - Increases elasticity (+22.7%).
    - Reduces wrinkles (–19.6%).
  • β-carotene :
    Provides increased photoprotection against UV rays .
  • Vitamin E and selenium :
    Modest effects alone , but antioxidant synergy when combined
  • In full formula :
    Overall improvement in firmness , radiance and wrinkles .
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Concentration and serenity ADHD

Clinical study

Description

Studies related to Concentration and Serenity aim to:

  • To evaluate the efficacy of a 3-in-1 natural nutraceutical formula for children with ADHD.
  • Find out if this composition is an alternative or complement to psychostimulants (methylphenidate type), particularly for patients who are intolerant or have failed treatment.
  • Compile more than 20 cited scientific references : clinical trials on saffron, Bacopa, magnesium, zinc, choline, probiotics, etc.
  • Study the identified mechanisms of action: modulation of neurotransmitters (dopamine, serotonin, GABA), reduction of oxidative stress, regulation of inflammation and neuronal plasticity.
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Results

  • Effect comparable to Ritalin (methylphenidate) on the main symptoms of ADHD (inattention, hyperactivity, impulsivity), without the major side effects of psychostimulants (saffron).
  • Improvement in hyperactivity more marked than under methylphenidate in certain studies (saffron), with better sleep (sleep latency + duration).
  • Reduction of attention deficit and agitation in 85–93% of children in studies using Bacopa monnieri.
  • Decreased impulsivity and improved emotional control observed with choline and B vitamins (especially B6 and B12).
  • Significant reduction in aggression, agitation and improvement in concentration thanks to the combination of magnesium + vitamin B6 (French studies).
  • Improved mood and emotional well-being with saffron (antidepressant effect documented in ADHD and mild anxiety disorders)
  • Improvement of digestive comfort and sleep thanks to specific probiotics ( Bifidobacterium breve , Lactobacillus rhamnosus GG , B. longum 1714 ), having demonstrated an anxiolytic and neuroprotective effect.
  • Experimental evidence of a causal link between altered microbiota and hyperactivity (ADHD microbiota transplantation inducing hyperactivity in animals).
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