• The studies investigated the effects of Bifidobacterium lactis B420 in overweight or obese adults.
• Main objectives:
  - Assess the impact on body composition (reduction in fat mass).
  - Measure the effects on intestinal health (permeability, inflammation).
  - Study the influence on appetite and metabolic markers .
• Studies conducted under clinical and preclinical conditions, with or without associated prebiotic fibers .
• Purpose: To validate the potential of B420 as a natural solution for weight management and the prevention of metabolic disorders.

• B420 resulted in a significant reduction in total fat mass (–4.5%) and waist circumference (–2.4 cm).
• A spontaneous decrease in caloric intake of approximately 300 kcal/day was observed.
• The combination with prebiotic fibers reinforced the effects on:
  - Satiety ,
  - Intestinal permeability (reduction of zonulin),
  - Inflammation (decrease in ultrasensitive CRP).
• Preclinical studies have shown:
  - Improved insulin sensitivity ,
  - A reduction in circulating endotoxins .
• Bottom Line: B420 is one of the most well-documented probiotic strains for reducing fat mass and supporting gut and metabolic health.

• The studies investigated the efficacy of Lactobacillus crispatus, L. rhamnosus and L. reuteri .
• Main objectives:
  -Restore a protective vaginal microbiota .
  -Prevent recurrent infections : bacterial vaginosis and candidiasis.
  -Reduce imbalances linked to antibiotic therapy, stress or hormonal variations.
• Clinical trials also evaluated:
  - The impact on vaginal pH .
  - Reduction of intimate symptoms : discharge, irritation, dryness.
• Improving the quality of life of women .

• The three strains ensure rapid and lasting recolonization of the vaginal flora.
• They maintain a low vaginal pH and a dominance of protective lactobacilli .
• Reduction of recurrences of vaginosis and candidiasis by 45 to 60% .
• Extension of infection-free periods observed.
• Lactobacillus reuteri produces reuterin , a natural antimicrobial active against Candida and Gardnerella .
• Women report a marked improvement in intimate comfort :
  - Less losses,
  - Less irritation
  - Fewer post-antibiotic imbalances.
• The effects are synergistic and clinically well tolerated .

• Clinical studies have evaluated the adaptogenic effects of ashwagandha , traditionally used in Ayurvedic medicine.
• Main objectives:
  - Reduce stress and anxiety .
  - Improve sleep and cognition .
  - Optimize physical performance and hormonal balance .
  - Support fertility , immunity and metabolic health .
• The trials included stressed adults , insomniacs , athletes , and subjects with hormonal or cognitive disorders .
• The studies aimed to:
  -Confirm the effectiveness of ashwagandha.
  -Determine the optimal doses according to the indications.
  -Document its tolerance and safety of use .

• Stress reduction : reduction of cortisol by –14 to –20%
• Decreased anxiety : large effect (SMD ≈ –1.5).
• Improved sleep : quality, duration and ease of falling asleep.
• Strengthening cognitive abilities : memory and concentration.
• Increased strength and endurance in athletes.
• Hormonal effects :
  - Increased testosterone and improved sperm quality .
  - Improvement of female sexual function .
• Immune support : increase in lymphocytes , antibodies and NK cells .
• Metabolic balance : regulation of blood sugar, blood lipids and possible improvement of mild hypothyroidism .
• Anti-inflammatory and antioxidant action contributing to overall well-being.

• The studies evaluate the efficacy of the combination of L. acidophilus, L. rhamnosus and B. infantis in children aged 1 to 15 years.
• Three axes are explored: immunity/infections , functional digestive disorders (IBS, pain), and acute diarrhea (including post-antibiotics).
• The objective is to validate the pediatric use of these strains in well-tolerated multi-strain formulas.
• Research also focuses on safety , duration of treatment and optimal dosage .
• This work supports the targeted use of probiotics in prevention and treatment in children .

• The combination of L. acidophilus, L. rhamnosus and B. infantis shows significant efficacy in children in several areas.
• It reduces respiratory infections (less fever, cough and need for antibiotics).
• It relieves pain and bloating associated with irritable bowel syndrome, with good tolerance.
• In case of acute diarrhea , it accelerates the return to normal transit .
• It prevents post-antibiotic diarrhea , with excellent clinical tolerance .

• Studies evaluate the effectiveness of specific nutrients on the growth, strength and quality of hair and nails .
• They cover plants (nettle, horsetail), minerals (zinc, magnesium), B vitamins (B5, B6, B8), amino acids (cystine, MSM) and collagen peptides .
• The research combines in vitro studies, controlled clinical trials and observational studies .
• The goal is to identify bioactive compounds that strengthen keratin and stimulate hair follicles .

• Silica, L-cystine, MSM, marine collagen, zinc and biotin improve the quality of hair and nails, especially in cases of deficiency.
• Nettle and horsetail show positive effects in cell culture or in combination use, but lack strong isolated clinical evidence
• Hydrolyzed collagen stimulates nail growth and follicular activity .
• Combined formulas containing several of these active ingredients are the most effective .
• They help strengthen hair , thicken nails and reduce hair loss or breakage .

• Urgence Détox studies evaluate the effectiveness of medicinal plants in protecting and regenerating the liver and analyze their impact on oxidative stress and improving digestive functions.
• Research focuses on extracts such as artichoke, milk thistle or turmeric , and their effect on liver markers (ALT, AST) , bile production and digestive enzyme activity .
• The data combine clinical trials (e.g., hepatic steatosis) and preclinical studies on antioxidant and anti-inflammatory mechanisms.
• Certain plants are also studied for their positive effects on the intestinal microbiota , in a synergistic approach to natural detoxification .

• Clinical studies show that artichoke, milk thistle and turmeric significantly improve liver markers (ALT, AST) and symptoms of liver diseases.
• Dandelion and rosemary show promising antioxidant and hepatoprotective effects , particularly in preclinical studies .
• Peppermint relieves functional digestive disorders , such as bloating.
• Lemon balm and fumitory support digestion and help modulate the intestinal microbiota .
• All of these plants act in synergy on liver detox , reduction of oxidative stress and digestive comfort .

• The studies aim to evaluate the effectiveness of a specific combination of probiotics on acute and chronic digestive disorders .
• They examine their impact on infectious diarrhea , post-antibiotic imbalances , irritable bowel syndrome (IBS) , constipation and bloating .
• The objective is also to measure their effects on the regulation of transit , the reduction of inflammation and the protection of the mucous barrier.
• The approach is based on the synergy of three major strains acting in a complementary manner.
• Research also evaluates high-dose tolerance and the benefits in prevention and treatment.

• Rapid effectiveness from 4 weeks against acute and chronic digestive disorders clinically proven.
• Reduction of infectious and post-antibiotic diarrhea , improvement of constipation , bloating and pain related to IBS .
• All three strains strengthen the intestinal barrier , regulate the microbiota and support local immunity .
• The probiotic synergy acts both curatively and preventively , with very good clinical tolerance .
• The results are validated by several reference clinical trials on each of the strains.

• Studies evaluate the preventive and therapeutic effects of omega-3 on various vital functions.
• They demonstrate a reduction in cardiovascular risks , particularly after a heart attack (e.g. GISSI study).
• Research confirms their role in maintaining age-related cognitive functions (e.g., MIDAS study).
• Omega-3s are being studied for their effectiveness on eye health , particularly against AMD (e.g. AREDS2).
• Several studies highlight their anti-inflammatory action , particularly in diseases such as arthritis.

• Omega-3 EPA and DHA have demonstrated proven clinical efficacy in several health areas.
• They reduce post-infarction cardiovascular mortality by 20% (GISSI study).
• They improve memory in older people (MIDAS study)
• They slow the progression of AMD (AREDS2 study) and reduce joint inflammation (Calder study).
• These effects are obtained with doses of 850 to 900 mg/day , validated by reference clinical trials

• Clinical studies on magnesium evaluate its effects on cardiovascular, nervous, muscular, immune and bone health.
• They examine its role in regulating blood pressure , muscle recovery , stress management and improving sleep .
• Magnesium is also being studied for its impact on carbohydrate metabolism , particularly in type 2 diabetes .
• Other research focuses on its anti-inflammatory effects and its role in bone mineralization , especially in people who are deficient.
• The overall objective is to identify the optimal forms, doses and durations of treatment for each indication.

• Magnesium moderately lowers blood pressure in untreated hypertensive patients.
• It improves glycemic control in diabetics, especially in cases of deficiency.
• It does not reduce idiopathic cramps , but promotes muscle recovery and reduces stress , especially with vitamin B6.
• It improves sleep and mood in vulnerable people
• It supports bone health , modulates inflammation and has good clinical tolerance .

• Clinical studies are evaluating Lactiplantibacillus plantarum DR7 to prevent ENT infections , particularly in stressed adults.
• They analyze its impact on mucosal immunity , by modulating the innate and adaptive immune response.
• The objective is to measure the reduction in the frequency, duration and severity of infections.
• The main study is a double-blind, randomized trial of 111 adults .
• This research also explores the effect of DR7 as immune support in the context of chronic psychological stress .

• Lactiplantibacillus plantarum DR7 significantly reduces the number, duration and severity of ENT infections.
• It increases salivary IgA levels , strengthening local mucosal immunity.
• It is well tolerated and remains effective in stressful situations.
• Magnesium and Fibersol complement the immune effect by supporting the nervous system and intestinal balance .
• The entire formula works in synergy to strengthen natural defenses .

• Clinical studies are evaluating glucomannan (konjac fiber) for its effects on satiety and weight loss .
• They examine its action on lipid and carbohydrate metabolism , particularly in diabetic people.
• Glucomannan is being studied for its prebiotic effects promoting a healthy gut microbiota.
• Its role on intestinal function , particularly in constipated subjects, is also documented.
• The objective is to validate its usefulness in nutritional supplementation for obese, diabetic or constipated profiles.

• Glucomannan increases satiety and significantly reduces appetite .
• It lowers LDL and total cholesterol , and slightly improves fasting blood sugar .
• It is effective against constipation , by increasing the frequency and quality of stools.
• It favorably modifies the microbiota , in particular by enriching bifidobacteria
• It promotes the production of short-chain fatty acids (SCFAs) , which are beneficial for intestinal health.

• Studies are evaluating glutamine for its role in muscle recovery and athletic support .
• It is being studied to restore the integrity of the intestinal mucosa and reduce permeability .
• Its effect is analyzed on immunity in the context of stress (resuscitation, cancer, intense exercise).
• Glutamine may modulate oxidative stress and accelerate tissue healing
• The goal is to define the optimal clinical conditions and dosages to obtain a measurable benefit.

• Glutamine does not improve athletic performance , but it does promote muscle recovery .
• It reduces certain stress markers (CK, CRP, MDA) after exercise
• It is very effective in post-infectious IBS with intestinal hyperpermeability .
• In oncology , it reduces the severity of mucositis induced by chemotherapy.
• It has a slight anti-inflammatory and antioxidant effect , according to clinical studies.

These studies confirm through clinical trials or meta-analyses the physiological effects of the ingredients: immunity, energy, cognition, stress, beauty, etc.

• Immunity support with vitamin C, E, zinc, selenium and iodine – to better resist infections and regulate natural defenses.
• Energy and vitality with B vitamins (B1, B2, B3, B5, B6, B9, B12) and magnesium – to reduce fatigue, support metabolism and improve concentration.
• Nervous balance and mood : magnesium, B6, B12 and folates act synergistically on the management of stress, sleep and neurotransmitters (dopamine, serotonin).
• Beauty of skin, hair and nails : biotin, zinc, vitamin A and B2 strengthen cell regeneration, skin elasticity and hair health.
• Overall antioxidant protection : vitamins C, E, selenium and zinc neutralize free radicals and slow down cellular aging.
• Muscle and bone function : Calcium, phosphorus, magnesium, and potassium support muscle contraction, bone density, and fluid balance.
• Cognitive functions and memory : B1, B6, B12, folates and magnesium contribute to mental alertness, concentration and the prevention of cognitive fog.
  

• Studies evaluate the effects of essential amino acids (EAAs) on protein synthesis , physical performance , and muscle recovery .
• They examine their role in reducing post-exercise fatigue and preventing muscle damage (DOMS, creatine kinase).
• The research includes short- and long-term trials in young and old people .
• The effectiveness of EAAs is studied when taken pre- or post-workout .
• The objective is to validate their usefulness in maintaining muscle mass and optimizing sports performance.

• EAAs stimulate muscle protein synthesis from 6 g and improve post-exercise nitrogen balance .
• Taken before exercise , they reduce the loss of strength and lactatemia , limiting immediate fatigue.
• Taken after exercise , they reduce muscle damage , pain and perceived fatigue .
• Long-term studies show better maintenance of muscle mass , particularly in seniors.
• EAAs provide overall recovery support , without noticeable side effects.

• Studies have evaluated the effectiveness of marine collagen hydrolysate, including Aquacol™.
• Target population: adults showing signs of aging or tissue fragility.
• Main objectives:
• Improve the quality of skin, hair and nails
• Measure the impact on wrinkles, hydration, skin elasticity.
• Assess hair density, thickness and shedding.
• Studies tested different doses to identify the optimal effect.
• The safety and tolerability of the product were analyzed in healthy subjects.

• Study carried out in 2023 on the effectiveness of Aquacol™ (1 to 5 g/d).
• Significant aesthetic results observed:
• 61.9% reduction in wrinkles.
• Increased skin hydration by 22.9%.
• 25.7% increase in capillary thickness.
• 53.7% reduction in hair loss.
• Improvement also noted in skin elasticity and hair density.
• Perfect tolerance: 100% of subjects reported no adverse effects.
• Conclusion: Aquacol™ provides comprehensive anti-aging support for skin, hair and nails.

• Clinical and preclinical studies have evaluated the effects of berberine on several metabolic parameters.
• Main objectives:
  - Reduction in weight , blood sugar and blood lipids .
  - Improved intestinal health .
• Targeted indications:
  -Type 2 diabetes ,
  -Metabolic syndrome ,
  -Hepatic steatosis ,
• Digestive disorders , including IBS-D (irritable bowel syndrome with diarrhea predominance) .
• Mechanisms of action explored:
• Activation of AMPK (cellular energy regulation),
• Modulation of the intestinal microbiota ,
• Strengthening the intestinal barrier .

• Reduction in fasting blood glucose of approximately –14 mg/dL.
• Decrease in HbA1c from –0.5 to –2%, with improved insulin sensitivity (decrease in HOMA-IR).
• Metabolic effects comparable to those of metformin .
• Decreased triglycerides (~–24 mg/dL) and LDL cholesterol .
• Moderate weight loss (~–2 kg).
• Activation of fat burning (brown adipose tissue) and reduction of storage (browning of white tissue).
• Rebalancing of the intestinal microbiota , repair of the mucosa and reduction of inflammation.
• Improvement of digestive disorders , including IBS-D (irritable bowel with diarrhea).