Summary of results

• B420 resulted in a significant reduction in the total fat mass (–4.5%) and waist size (–2.4 cm).
• A spontaneous decrease in calorie intake of about 300 kcal/day was observed.
• The association with prebiotic fibers reinforced the effects on:
  - There satiety ,
  - There intestinal permeability (zonulin reduction),
  - Inflammation (decrease in ultrasensitive CRP).
• THE preclinical studies have shown:
  - An improvement in the insulin sensitivity ,
  - A reduction of circulating endotoxins .
• Conclusion : B420 is one of the most documented probiotic strains for fat mass reduction and support of intestinal and metabolic health.

Clinical efficacy of the formula “ Bio slimming B420 » and its probiotics

Clinical studies on the formula Bio slimming B420

The strain Bifidobacterium animalis ssp. lactis 420 (B420) has been evaluated in several high-quality clinical studies, including by Stenman et al., 2016 in a multicenter, randomized, double-blind, placebo-controlled trial involving 225 overweight or obese adults for 6 months. The results show a significant reduction in total fat mass of 4.5% (approximately 1.4 kg) in participants who received B420 combined with prebiotic fibers, compared to placebo.

A decrease in waist circumference by 2.4 cm was also observed. The study highlights a reduction in daily energy intake of approximately 300 kcal , suggesting a beneficial effect on satiety.
In addition, a improvement of intestinal permeability (decrease in zonulin) as well as a reduction of inflammatory markers (hs-CRP) were observed.
(Source: Stenman LK et al., EBioMedicine , 2016 – link to the study ).

Additional preclinical studies show that B420 improves the insulin sensitivity , reduces tissue inflammation and decreases the circulating levels of lipopolysaccharides (LPS) , endotoxins associated with obesity and type 2 diabetes. In addition, combining B420 with prebiotic fibers such as polydextrose has been shown to enhance these beneficial effects on body composition and metabolic markers (Source: DMS Journal ).

A review of the scientific literature highlights that B420 is one of the most well-documented strains for weight management and metabolic health , with over 30 clinical publications and 90 scientific publications in total (Source: Health Sciences IFF ). The Metagenics Institute also published a detailed review confirming the benefit of B420 in reducing body fat, improving the intestinal barrier, and supporting overall metabolic health (Source: Metagenics Institute ).

In conclusion, scientific data demonstrate that Bifidobacterium lactis B420 is particularly effective in promoting fat loss, strengthening gut health, reducing systemic inflammation and supporting a healthy metabolism, making this strain a valuable natural ally for weight management and metabolic prevention.