Summary of results

• B420 resulted in a significant reduction in the total fat mass (–4.5%) and waist size (–2.4 cm).
• A spontaneous decrease in calorie intake of about 300 kcal/day was observed.
• The association with prebiotic fibers reinforced the effects on:
  - There satiety,
  - There intestinal permeability (zonulin reduction),
  - L'inflammation (decrease in ultrasensitive CRP).
• THE preclinical studies have shown:
  - An improvement in the insulin sensitivity,
  - A reduction of circulating endotoxins.
• Conclusion : B420 is one of the most documented probiotic strains for fat mass reduction and support of intestinal and metabolic health.
• Lactobacillus gasseri leads to a decrease in abdominal fat by approximately 8 to 9%
• Fibersol improves the insulin sensitivity and causes a decrease in inflammation.

Clinical efficacy of the formula “ Bio slimming B420 » and its probiotics

B420

The strain Bifidobacterium animalis ssp. lactis 420 (B420) has been evaluated in several high-quality clinical studies, including by Stenman et al., 2016 in a multicenter, randomized, double-blind, placebo-controlled trial involving 225 overweight or obese adults for 6 months. The results show a significant reduction in total fat mass of 4.5% (approximately 1.4 kg) in participants who received B420 combined with prebiotic fibers, compared to placebo.

A decrease in waist circumference by 2.4 cm was also observed. The study highlights a reduction of daily energy intake of approximately 300 kcal, suggesting a beneficial effect on satiety.
In addition, a improvement of intestinal permeability (decrease in zonulin) as well as a reduction of inflammatory markers (hs-CRP) were observed.
(Source: Stenman LK et al., EBioMedicine, 2016 – link to the study).

Additional preclinical studies show that B420 improves the insulin sensitivity, reduces thetissue inflammation and decreases the circulating levels of lipopolysaccharides (LPS), endotoxins associated with obesity and type 2 diabetes. In addition, the combination of B420 with prebiotic fibers such as polydextrose has been shown to enhance these beneficial effects on body composition and metabolic markers (Source: DMS Journal).

A review of the scientific literature highlights that B420 is one of the most researched strains for weight management and metabolic health, with more than 30 clinical publications and 90 scientific publications in total (Source: Health Sciences IFF). THE Metagenics Institute also published a detailed review confirming the benefit of B420 in reducing body fat, improving the intestinal barrier, and supporting overall metabolic health (Source: Metagenics Institute).

In conclusion, scientific data demonstrate that Bifidobacterium lactis B420 is particularly effective in promoting fat loss, strengthening gut health, reducing systemic inflammation and supporting a healthy metabolism, making this strain a valuable natural ally for weight management and metabolic prevention.

Okay, here's one version continue, without bullet points, which includes the results of clinical studies for Lactobacillus gasseri, inulin (FOS) and Fibersol on weight loss:

Lactobacillus gasseri

Several human clinical trials have evaluated the impact of Lactobacillus gasseri on weight loss. Kadooka et al. (2010) showed, in a 12-week controlled trial on overweight adults, that consumption of fermented milk enriched with L. gasseri SBT2055 resulted in a significant reduction in visceral and subcutaneous fat, BMI, and waist circumference.
A larger study conducted in 2013 by the same team (210 participants) confirmed these results, with a decrease in abdominal fat of approximately 8 to 9% and an improvement in BMI and total fat mass, although the effect tended to diminish after stopping supplementation.
Other studies, particularly with the BNR17 strain (Jung et al., 2013; Kim et al., 2018), have also reported a reduction in waist circumference and visceral fat, sometimes without marked overall weight loss but with a targeted improvement in body composition. Finally, animal studies, such as that of Kang et al. (2013), confirm these results by showing a limitation of weight gain and an improvement in fat oxidation in mice subjected to a high-calorie diet.

Inulin (FOS)

Nicolucci et al. (2017) observed, in 42 overweight children supplemented for 16 weeks with 8 g/d of enriched inulin, a reduction in total and abdominal adiposity as well as an improvement in the inflammatory and lipid profile.
In adults, Guess et al. (2015) showed that supplementation with 15 g/d of inulin in prediabetic subjects promoted continued weight loss after an initial diet and reduced liver and muscle fat.
In the Food4Gut trial (Hiel et al., 2020), 16 g/d of inulin for three months in 150 obese adults on a low-calorie diet resulted in greater weight loss than placebo, with a decrease in insulin levels. In contrast, a more recent study (Visuthranukul et al., 2022) in 110 obese children showed no additional weight loss compared to placebo, although lean mass was slightly improved.

Fibersol (resistant dextrin)

Regarding Fibersol, clinical data mainly suggest an effect on satiety and, in some cases, modest weight loss. Ye et al. (2015) showed that 10 g of Fibersol taken with a meal delays the reappearance of hunger and stimulates the secretion of satiety hormones such as GLP-1 and peptide YY.A Chinese trial (Li et al., 2010) in 113 overweight adults demonstrated that a high dose of 34 g/d of Fibersol for 12 weeks resulted in an additional weight loss of approximately 1.5 kg compared to placebo.
However, other studies, such as that of Aliasgharzadeh et al. (2015) in diabetic women, did not show a significant effect on weight but highlighted an improvement in insulin sensitivity and a decrease in inflammation. A meta-analysis by Mukai et al. (2017), grouping together several clinical trials, concluded that Fibersol induces a modest but significant weight loss (on average –0.8 kg in 8 to 12 weeks, with a more marked effect at high doses and on visceral fat).
Animal studies, such as that of Hu et al. (2020), confirm these results by showing a reduction in weight gain and metabolic inflammation in mice subjected to a high-calorie diet.