Summary of results
Clinical studies on the formula Sleep more
L-tryptophan, an essential amino acid involved in the production of serotonin and melatonin, plays a crucial role in emotional well-being, sleep, and immunity. Its interactions with the gut microbiota are varied and highlight the importance of this amino acid in maintaining intestinal and systemic balance. Here are the main relationships between L-tryptophan and the microbiota:
Source of precursors for neurotransmitters
L-tryptophan is metabolized by the microbiota to produce serotonin, which is essential for regulating mood, stress, and sleep. A large portion of the body's serotonin (about 90%) is produced in the gut under the influence of certain beneficial bacteria such as Lactobacillus And Bifidobacterium.
Impact on the gut-brain axis
The microbiota modulates the absorption and metabolism of L-tryptophan, influencing its use for neurotransmitter synthesis and gut-brain communication. A balanced microbiota promotes better availability of L-tryptophan for optimal gut-brain axis function.
Production of tryptophan-derived metabolites
Gut bacteria convert L-tryptophan into metabolites such as indole, kynurenine, and other compounds. These metabolites play a role in immune regulation and reducing systemic inflammation, positively influencing gut health.
Reduction of intestinal inflammation
Metabolites produced from L-tryptophan by the microbiota help modulate inflammation in the gut, promoting the production of anti-inflammatory cytokines and reducing levels of pro-inflammatory cytokines.
Strengthening the intestinal barrier
L-tryptophan and its derivatives strengthen the intestinal barrier by stimulating the production of tight junction proteins. This mechanism limits intestinal permeability and prevents the passage of pathogens and toxins into the bloodstream, thus preserving the overall health of the microbiota.
Regulation of the microbiota
A diet rich in L-tryptophan can promote the abundance of beneficial bacteria, thereby improving bacterial diversity and limiting the growth of pathogenic bacteria.
Effect on sleep and stress
L-tryptophan, by participating in the synthesis of melatonin, has a direct effect on sleep. Since stress often disrupts the microbiota, L-tryptophan supplementation can reduce intestinal imbalances by modulating the stress response via the gut-brain axis.
Conclusion
L-tryptophan maintains complex and beneficial relationships with the gut microbiota, influencing the gut-brain axis, reducing inflammation, and strengthening the intestinal barrier. In turn, a healthy microbiota supports the effective use of L-tryptophan to maximize its benefits for emotional, immune, and digestive health.