Emergency Detox: Targeted on rapid detoxification

L-Tryptophan is an essential amino acid that plays a crucial role not only in the production of neurotransmitters like serotonin but also in the health of the gut microbiota. Here are the main links between L-Tryptophan and the microbiota:

1. Synthesis of serotonin and influence on the microbiota

Intestinal serotonin: Approximately 90% of the body's serotonin is produced in the gut. This production is influenced by L-Tryptophan and modulated by specific gut bacteria, such as certain strains ofLactobacillusAndBifidobacterium.

Impact on intestinal motility: Serotonin plays a key role in regulating intestinal movements and transit, indirectly influencing the composition and balance of the microbiota.

2. Metabolites from L-Tryptophan and interactions with the microbiota

Indole and derivatives: Some gut bacteria convert L-Tryptophan into indole and related compounds (such as indole-3-acetic acid and indoxyl sulfate). These metabolites:

Kynurenine acid: Part of L-Tryptophan is converted to kynurenine via the IDO (indolamine 2,3-dioxygenase) metabolic pathway. Kynurenine levels are linked to local immunity and microbiota.

3. Role in intestinal inflammation and immune homeostasis

L-Tryptophan influences the immune response through its impact on AHR receptors (aryl hydrocarbon receptors), which play a role in regulating the immunity of the intestinal mucosa.

In cases of imbalances (such as in irritable bowel syndrome or inflammatory bowel diseases), L-tryptophan metabolism is often impaired, affecting bacterial composition.

4. Effects on stress and the link with the gut-brain axis

Low L-tryptophan intake or poor conversion to serotonin can worsen stress and anxiety. Given the interconnectedness between the microbiota and the gut-brain axis, this can also negatively influence the microbiota.

Some probiotic bacteria (e.g.,Bifidobacterium longum) help optimize L-Tryptophan availability and promote balanced serotonin levels.

Summary of benefits for the microbiota

Maintaining the intestinal barrier: Reduction of intestinal permeability via indole metabolites.

Modulation of inflammation: Beneficial effects on immune balance.

Optimizing mental health: Influence on the gut-brain axis through serotonin.

Support for good bacteria: Promotes the growth of beneficial strains and limits pathogenic bacteria.

L-Tryptophan therefore plays both a direct and indirect role in the regulation of the intestinal microbiota and contributes to the overall health of the gut-brain axis.

Here is an overview of clinical and preclinical studies regarding the effectiveness of the plants mentioned for liver and digestive detoxification:

Artichoke (Cynara scolymus)

Clinical trials have shown that artichoke leaf extract significantly reduces liver enzymes (ALT, AST) in patients with non-alcoholic fatty liver disease (NAFLD), suggesting a hepatoprotective effect.(PubMed)

Milk thistle (Carduus marianus)

Silymarin, the active ingredient in milk thistle, has been extensively studied for its antioxidant and hepatoprotective effects. Clinical trials have shown improvements in liver enzymes and symptoms in patients with chronic liver disease.

Chrysanthellum americanum

Preclinical studies suggest that this plant has hepatoprotective properties thanks to its flavonoids and saponins. It also promotes blood circulation.

Fumaria (Fumaria officinalis)

Traditionally used to stimulate bile production and support liver function, studies suggest it has antioxidant and hepatoprotective properties.

Peppermint (Mentha piperita)

Clinical trials have shown that peppermint oil can relieve symptoms of irritable bowel syndrome, such as bloating and abdominal pain.(PubMed)

Dandelion (Taraxacum officinale)

Animal studies have shown that dandelion root extract has hepatoprotective effects, including reducing markers of oxidative stress and improving liver function.

Rosemary (Rosmarinus officinalis)

Rosemary contains rosmarinic acid, which has shown antioxidant and hepatoprotective effects in preclinical studies.

Lemon balm (Melissa officinalis)

Studies have shown that lemon balm has antioxidant properties and can modulate the gut microbiota, suggesting a potential role in digestive health.(Darwin Nutrition)

Bupleurum (Bupleurum chinense)

Used in traditional Chinese medicine to treat liver disorders, modern research on its hepatoprotective effects is still limited.

Turmeric (Curcuma longa)

Turmeric, and particularly curcumin, has shown beneficial effects on liver function, including reducing liver enzymes and improving lipid parameters in patients with NAFLD.(BioMed Central)

Conclusion :

Among these plants, artichoke, milk thistle, and turmeric have the strongest clinical evidence regarding their beneficial effects on liver function.
Others, such as dandelion, rosemary, and peppermint, show promising results mainly from preclinical studies or medicinal tradition.
It is important to consult a healthcare professional before starting any herbal treatment, especially in cases of liver disease.